Biotech · Public company · Lexington, MA, US
Agenus Inc
Ticker AGEN · SEC CIK 0001098972
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Clinical trials2516 recruiting or active
Pipeline programs17From trials and the company's site
Disclosed deals0None found yet
Cash runwayNot availableNo recent cash burn filed
Pipeline17
- AGEN1884Phase 2 · Cervical CancerClinicalTrials.gov · fetched Nov 12, 2026
- AGEN2034Phase 2 · Cervical CancerClinicalTrials.gov · fetched Nov 12, 2026
- BalstilimabPhase 2 · Advanced MelanomaClinicalTrials.gov · fetched Nov 12, 2026
- BalstilimabPhase 2 · Metastatic Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- BalstilimabPhase 2 · Cervical CancerClinicalTrials.gov · fetched Nov 12, 2026
- BotensilimabPhase 2 · Metastatic Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- BotensilimabPhase 2 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- BotensilimabPhase 2 · Advanced MelanomaClinicalTrials.gov · fetched Nov 12, 2026
- GemcitabinePhase 2 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- Nab-paclitaxelPhase 2 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- ZalifrelimabPhase 2 · Cervical CancerClinicalTrials.gov · fetched Nov 12, 2026
- a PD-1 inhibitorPhase 1 · Advanced CancerClinicalTrials.gov · fetched Nov 12, 2026
- AGEN1777Phase 1 · Advanced CancerClinicalTrials.gov · fetched Nov 12, 2026
- BalstilimabPhase 1 · Advanced CancerClinicalTrials.gov · fetched Nov 12, 2026
- BotensilimabPhase 1 · Advanced CancerClinicalTrials.gov · fetched Nov 12, 2026
- BalstilimabCancerClinicalTrials.gov · fetched Nov 12, 2026
- ZalifrelimabCancerClinicalTrials.gov · fetched Nov 12, 2026
Clinical trials25
- RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal CancerPHASE2 · RECRUITING · started Aug 10, 2026ClinicalTrials.gov NCT07735624 · fetched Nov 12, 2026
- Botensilimab, Balstilimab, and SBRT in Colorectal CancerEARLY_PHASE1 · RECRUITING · started May 12, 2026ClinicalTrials.gov NCT07128355 · fetched Nov 12, 2026
- A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and ChemotherapyPHASE2 · RECRUITING · started Nov 7, 2025ClinicalTrials.gov NCT07227636 · fetched Nov 12, 2026
- The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-RadiationPHASE2 · RECRUITING · started Jun 18, 2025ClinicalTrials.gov NCT06843551 · fetched Nov 12, 2026
- Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic CancerPHASE1_PHASE2 · RECRUITING · started May 27, 2025ClinicalTrials.gov NCT06782932 · fetched Nov 12, 2026
- A Study of Botensilimab and Balstilimab for Rectal AdenocarcinomaPHASE2 · RECRUITING · started Feb 20, 2025ClinicalTrials.gov NCT06843434 · fetched Nov 12, 2026
- The Seven Trial: Exploiting the Unfolded Protein ResponsePHASE1 · TERMINATED · started Jan 9, 2025ClinicalTrials.gov NCT06076837 · fetched Nov 12, 2026
- A Study of Evofosfamide in Combination With Zalifrelimab and BalstilimabPHASE1_PHASE2 · ACTIVE_NOT_RECRUITING · started Jan 8, 2025ClinicalTrials.gov NCT06782555 · fetched Nov 12, 2026
- Botensilimab and Balstilimab Optimization in Colorectal CancerPHASE2 · ACTIVE_NOT_RECRUITING · started Nov 18, 2024ClinicalTrials.gov NCT06268015 · fetched Nov 12, 2026
- KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal CancerPHASE1 · RECRUITING · started Nov 4, 2024ClinicalTrials.gov NCT06411691 · fetched Nov 12, 2026
- AGEN1423 and Botensilimab w/ or w/o Chemo in PDACPHASE2 · ACTIVE_NOT_RECRUITING · started Aug 8, 2024ClinicalTrials.gov NCT05632328 · fetched Nov 12, 2026
- Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver MetastasesPHASE2 · RECRUITING · started Mar 26, 2024ClinicalTrials.gov NCT06300463 · fetched Nov 12, 2026
- Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed GlioblastomaPHASE2 · ACTIVE_NOT_RECRUITING · started Jan 19, 2024ClinicalTrials.gov NCT05864534 · fetched Nov 12, 2026
- Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer and HR+/HER2- Metastatic Breast CancerPHASE1_PHASE2 · RECRUITING · started Oct 13, 2023ClinicalTrials.gov NCT05318469 · fetched Nov 12, 2026
- Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical TrialPHASE2 · SUSPENDED · started Sep 25, 2023ClinicalTrials.gov NCT05928806 · fetched Nov 12, 2026
- A Study of Botensilimab in Participants With Metastatic Pancreatic CancerPHASE2 · COMPLETED · started Mar 27, 2023ClinicalTrials.gov NCT05630183 · fetched Nov 12, 2026
- Combination Immunotherapy in Colorectal CancerPHASE2 · COMPLETED · started Mar 17, 2023ClinicalTrials.gov NCT05571293 · fetched Nov 12, 2026
- A Study of Botensilimab (AGEN1181) for the Treatment of Advanced MelanomaPHASE2 · TERMINATED · started Dec 12, 2022ClinicalTrials.gov NCT05529316 · fetched Nov 12, 2026
- A Study of Botensilimab and Balstilimab for the Treatment of Colorectal CancerPHASE2 · ACTIVE_NOT_RECRUITING · started Nov 30, 2022ClinicalTrials.gov NCT05608044 · fetched Nov 12, 2026
- A Study Investigating AGEN1777 in Participants With Advanced Solid TumorsPHASE1 · COMPLETED · started Oct 4, 2021ClinicalTrials.gov NCT05025085 · fetched Nov 12, 2026
- Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue SarcomasPHASE2 · ACTIVE_NOT_RECRUITING · started Jan 28, 2020ClinicalTrials.gov NCT04028063 · fetched Nov 12, 2026
- RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical CancerPHASE2 · TERMINATED · started Jun 1, 2019ClinicalTrials.gov NCT03894215 · fetched Nov 12, 2026
- Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced CancerPHASE1 · ACTIVE_NOT_RECRUITING · started Mar 20, 2019ClinicalTrials.gov NCT03860272 · fetched Nov 12, 2026
- A Study of Zalifrelimab and Balstilimab for Treatment of Participants With Metastatic or Locally Advanced Solid Tumors, and Expansion Into Select Solid Tumors (Cervical)PHASE1_PHASE2 · COMPLETED · started Dec 18, 2017ClinicalTrials.gov NCT03495882 · fetched Nov 12, 2026
- Expanded Access for Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)AVAILABLEClinicalTrials.gov NCT05572970 · fetched Nov 12, 2026
SEC filings12
- 10-Q · 10-QSEC EDGAR · filed Nov 5, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Nov 5, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Aug 18, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Aug 13, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Aug 11, 2026 · fetched Nov 12, 2026
- 10-Q · 10-QSEC EDGAR · filed Aug 7, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Aug 6, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Jul 13, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Jul 6, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed Jun 23, 2026 · fetched Nov 12, 2026
- 8-K · 8-KSEC EDGAR · filed May 15, 2026 · fetched Nov 12, 2026
- 10-Q · 10-QSEC EDGAR · filed May 11, 2026 · fetched Nov 12, 2026