Biotech · Private company
Cara Therapeutics, Inc.
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Clinical trials180 recruiting or active
Pipeline programs28From trials and the company's site
Disclosed deals0None found yet
Cash runwayNot availablePrivate: no SEC financials
Pipeline28
- CR845Phase 3 · Uremic PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 0.5 mcg/kgPhase 3 · Uremic PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 1 mcg/kgPhase 3 · Uremic PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 1.5mcg/kgPhase 3 · Uremic PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 IV 0.5 mcg/kgPhase 3 · Post Abdominal Surgery PainClinicalTrials.gov · fetched Nov 12, 2026
- CR845 IV 1 mcg/kgPhase 3 · Post Abdominal Surgery PainClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 0.25 mgPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 0.25 mg tabletsPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 0.5 mgPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- Difelikefalin 1 mg Oral TabletPhase 3 · Chronic Kidney DiseasesClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 1.0 mg tabletsPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 2.0 mg tabletsPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- TCS CreamPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- Vehicle CreamPhase 3 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 0.25 mg Oral TabletPhase 2 · Chronic Kidney DiseasesClinicalTrials.gov · fetched Nov 12, 2026
- CR845 0.5 mg Oral TabletPhase 2 · Chronic Kidney DiseasesClinicalTrials.gov · fetched Nov 12, 2026
- CR845 1 mg Oral TabletPhase 2 · Chronic Kidney DiseasesClinicalTrials.gov · fetched Nov 12, 2026
- CR845 1.0 mgPhase 2 · Cholestatic PruritusClinicalTrials.gov · fetched Nov 12, 2026
- CR845 tablet 1 mgPhase 2 · Osteoarthritis, HipClinicalTrials.gov · fetched Nov 12, 2026
- CR845 tablet 2.5 mgPhase 2 · Osteoarthritis, HipClinicalTrials.gov · fetched Nov 12, 2026
- CR845 tablet 5 mgPhase 2 · Osteoarthritis, HipClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 1.0 mgPhase 2 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- difelikefalin 2.0 mgPhase 2 · PruritusClinicalTrials.gov · fetched Nov 12, 2026
- [14C] CR845Phase 1 · HemodialysisClinicalTrials.gov · fetched Nov 12, 2026
- CR845 0.5 mcg/kgPhase 1 · HemodialysisClinicalTrials.gov · fetched Nov 12, 2026
- CR845 0.5 mcg/kg IVPhase 1 · HealthyClinicalTrials.gov · fetched Nov 12, 2026
- CR845 3 mcg/kg IVPhase 1 · HealthyClinicalTrials.gov · fetched Nov 12, 2026
- Moxifloxacin 400 mg Oral TabletPhase 1 · HealthyClinicalTrials.gov · fetched Nov 12, 2026
Clinical trials18
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects With Notalgia ParestheticaPHASE2_PHASE3 · TERMINATED · started Aug 1, 2023ClinicalTrials.gov NCT05978063 · fetched Nov 12, 2026
- CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe PruritusPHASE3 · TERMINATED · started Aug 26, 2022ClinicalTrials.gov NCT05356403 · fetched Nov 12, 2026
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid for Moderate to Severe Pruritus in Subjects With Atopic DermatitisPHASE3 · TERMINATED · started Aug 16, 2022ClinicalTrials.gov NCT05387707 · fetched Nov 12, 2026
- A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Moderate-to-Severe PruritusPHASE3 · TERMINATED · started May 17, 2022ClinicalTrials.gov NCT05342623 · fetched Nov 12, 2026
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)PHASE2 · COMPLETED · started Jan 11, 2021ClinicalTrials.gov NCT04706975 · fetched Nov 12, 2026
- CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in Hemodialysis PatientsPHASE1 · COMPLETED · started Dec 31, 2019ClinicalTrials.gov NCT05533008 · fetched Nov 12, 2026
- Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic DermatitisPHASE2 · COMPLETED · started Jun 29, 2019ClinicalTrials.gov NCT04018027 · fetched Nov 12, 2026
- Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe PruritusPHASE2 · TERMINATED · started Jun 25, 2019ClinicalTrials.gov NCT03995212 · fetched Nov 12, 2026
- Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy SubjectsPHASE1 · COMPLETED · started Jun 20, 2019ClinicalTrials.gov NCT04019574 · fetched Nov 12, 2026
- CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusPHASE3 · COMPLETED · started May 6, 2019ClinicalTrials.gov NCT03998163 · fetched Nov 12, 2026
- Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy SubjectsPHASE1 · COMPLETED · started Jan 17, 2019ClinicalTrials.gov NCT03947970 · fetched Nov 12, 2026
- CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusPHASE3 · COMPLETED · started Jul 17, 2018ClinicalTrials.gov NCT03636269 · fetched Nov 12, 2026
- A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe PruritusPHASE2 · COMPLETED · started Jul 5, 2018ClinicalTrials.gov NCT03617536 · fetched Nov 12, 2026
- A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)PHASE3 · COMPLETED · started Feb 20, 2018ClinicalTrials.gov NCT03422653 · fetched Nov 12, 2026
- Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusPHASE3 · COMPLETED · started Aug 14, 2017ClinicalTrials.gov NCT03281538 · fetched Nov 12, 2026
- A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or KneePHASE2 · COMPLETED · started Sep 1, 2016ClinicalTrials.gov NCT02944448 · fetched Nov 12, 2026
- Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe PruritusPHASE2_PHASE3 · COMPLETED · started Jun 1, 2016ClinicalTrials.gov NCT02858726 · fetched Nov 12, 2026
- A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdominal SurgeryPHASE2_PHASE3 · COMPLETED · started Sep 1, 2015ClinicalTrials.gov NCT02542384 · fetched Nov 12, 2026