Biotech · Private company

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

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Clinical trials218 recruiting or active

Pipeline programs19From trials and the company's site

Disclosed deals0None found yet

Cash runwayNot availablePrivate: no SEC financials

Pipeline19

KarX-ECPhase 3 · SchizophreniaClinicalTrials.gov · fetched Nov 12, 2026
KarXTPhase 3 · Psychosis Associated With Alzheimer's DiseaseClinicalTrials.gov · fetched Nov 12, 2026
KarXTPhase 3 · Alzheimer DiseaseClinicalTrials.gov · fetched Nov 12, 2026
KarXTPhase 3 · SchizophreniaClinicalTrials.gov · fetched Nov 12, 2026
Xanomeline and Trospium Chloride CapsulesPhase 3 · SchizophreniaClinicalTrials.gov · fetched Nov 12, 2026
Xanomeline/Trospium ChloridePhase 3 · SchizophreniaClinicalTrials.gov · fetched Nov 12, 2026
DigoxinPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
FexofenadinePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
KarX-ECPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
KarXTPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
LamotriginePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
LithiumPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
MidazolamPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
OmeprazolePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Valproic AcidPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Xanomeline/ Trospium ChloridePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
MeclizineHealthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
OndansetronHealthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
TrimethobenzamideHealthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026

Clinical trials21

Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy VolunteersPHASE4 · RECRUITING · started Sep 3, 2026ClinicalTrials.gov NCT07681076 · fetched Nov 12, 2026
Relapse Prevention Trial Evaluating KarXT Treatment in SchizophreniaPHASE3 · RECRUITING · started Aug 20, 2026ClinicalTrials.gov NCT07686263 · fetched Nov 12, 2026
A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and AdolescentsPHASE3 · RECRUITING · started Apr 7, 2026ClinicalTrials.gov NCT07424404 · fetched Nov 12, 2026
KarXT Concentrations in the Breast Milk and Plasma of Lactating FemalesPHASE4 · COMPLETED · started Jan 9, 2026ClinicalTrials.gov NCT07257120 · fetched Nov 12, 2026
A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult ParticipantsPHASE1 · RECRUITING · started Oct 13, 2025ClinicalTrials.gov NCT07204418 · fetched Nov 12, 2026
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and DigoxinPHASE1 · COMPLETED · started Sep 29, 2025ClinicalTrials.gov NCT07118215 · fetched Nov 12, 2026
A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy ParticipantsPHASE1 · COMPLETED · started Dec 26, 2024ClinicalTrials.gov NCT06729970 · fetched Nov 12, 2026
Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With SchizophreniaPHASE3 · COMPLETED · started Oct 28, 2024ClinicalTrials.gov NCT06572449 · fetched Nov 12, 2026
A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult ParticipantsPHASE1 · COMPLETED · started Oct 1, 2024ClinicalTrials.gov NCT06605950 · fetched Nov 12, 2026
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)PHASE3 · RECRUITING · started Sep 26, 2024ClinicalTrials.gov NCT06585787 · fetched Nov 12, 2026
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)PHASE3 · RECRUITING · started Aug 28, 2023ClinicalTrials.gov NCT06126224 · fetched Nov 12, 2026
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)PHASE3 · RECRUITING · started Jul 11, 2023ClinicalTrials.gov NCT05980949 · fetched Nov 12, 2026
An Open-label Study to Assess the Long-term Safety, Tolerability, Effectiveness, and Durability of Effect of KarXT in Patients With DSM-5 Diagnosis of SchizophreniaPHASE3 · TERMINATED · started Nov 8, 2022ClinicalTrials.gov NCT05643170 · fetched Nov 12, 2026
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)PHASE3 · RECRUITING · started Aug 23, 2022ClinicalTrials.gov NCT05511363 · fetched Nov 12, 2026
An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of SchizophreniaPHASE3 · COMPLETED · started Mar 7, 2022ClinicalTrials.gov NCT05304767 · fetched Nov 12, 2026
A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of SchizophreniaPHASE3 · COMPLETED · started Nov 12, 2021ClinicalTrials.gov NCT05145413 · fetched Nov 12, 2026
An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)PHASE3 · COMPLETED · started Jun 2, 2021ClinicalTrials.gov NCT04820309 · fetched Nov 12, 2026
A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3)PHASE3 · COMPLETED · started Apr 6, 2021ClinicalTrials.gov NCT04738123 · fetched Nov 12, 2026
An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-4)PHASE3 · COMPLETED · started Feb 1, 2021ClinicalTrials.gov NCT04659174 · fetched Nov 12, 2026
A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2)PHASE3 · COMPLETED · started Dec 16, 2020ClinicalTrials.gov NCT04659161 · fetched Nov 12, 2026
A Study to Assess Safety and Efficacy of KarXT in Adult Patients With SchizophreniaPHASE2 · COMPLETED · started Sep 18, 2018ClinicalTrials.gov NCT03697252 · fetched Nov 12, 2026