Biotech · Private company
Leap Therapeutics, Inc.
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Clinical trials131 recruiting or active
Pipeline programs31From trials and the company's site
Disclosed deals0None found yet
Cash runwayNot availablePrivate: no SEC financials
Pipeline31
- 300mg DKN-01Phase 2 · Endometrial CancerClinicalTrials.gov · fetched Nov 12, 2026
- 600mg DKN-01Phase 2 · Endometrial CancerClinicalTrials.gov · fetched Nov 12, 2026
- BevacizumabPhase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01Phase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 300mgPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 400mgPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 600mgPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- FOLFIRIPhase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- FOLFOXPhase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
- OxaliplatinPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- PaclitaxelPhase 2 · Endometrial CancerClinicalTrials.gov · fetched Nov 12, 2026
- Tislelizumab 200mgPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- Tislelizumab 400mgPhase 2 · Gastric CancerClinicalTrials.gov · fetched Nov 12, 2026
- AvelumabPhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- cisplatinPhase 1 · Carcinoma of Intrahepatic and Extra-hepatic Biliary SystemClinicalTrials.gov · fetched Nov 12, 2026
- CyclophosphamidePhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01Phase 1 · Carcinoma of Intrahepatic and Extra-hepatic Biliary SystemClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 150 mgPhase 1 · Esophageal NeoplasmsClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 300 mgPhase 1 · Esophageal NeoplasmsClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 300 mgPhase 1 · Multiple MyelomaClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01 600 mgPhase 1 · Multiple MyelomaClinicalTrials.gov · fetched Nov 12, 2026
- gemcitabinePhase 1 · Carcinoma of Intrahepatic and Extra-hepatic Biliary SystemClinicalTrials.gov · fetched Nov 12, 2026
- PaclitaxelPhase 1 · Esophageal NeoplasmsClinicalTrials.gov · fetched Nov 12, 2026
- PembrolizumabPhase 1 · Esophageal NeoplasmsClinicalTrials.gov · fetched Nov 12, 2026
- TRX518Phase 1 · Unresectable Stage III or Stage IV Malignant Melanoma or Other Solid Tumor MalignanciesClinicalTrials.gov · fetched Nov 12, 2026
- TRX518Phase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- TRX518 monotherapyPhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- TRX518 with gemcitabinePhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- TRX518 with nivolumabPhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- TRX518 with pembrolizumabPhase 1 · Solid TumorsClinicalTrials.gov · fetched Nov 12, 2026
- DKN-01Esophageal NeoplasmClinicalTrials.gov · fetched Nov 12, 2026
Clinical trials13
- Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial CancerPHASE2 · ACTIVE_NOT_RECRUITING · started Aug 29, 2023ClinicalTrials.gov NCT05761951 · fetched Nov 12, 2026
- Phase 2 Study of DKN-01 in Colorectal CancerPHASE2 · COMPLETED · started Aug 30, 2022ClinicalTrials.gov NCT05480306 · fetched Nov 12, 2026
- A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal CancerPHASE2 · TERMINATED · started Jul 29, 2020ClinicalTrials.gov NCT04363801 · fetched Nov 12, 2026
- Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients With Advanced Biliary Tract Cancer (BTC)PHASE2 · TERMINATED · started Oct 7, 2019ClinicalTrials.gov NCT04057365 · fetched Nov 12, 2026
- A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid TumorsPHASE1 · TERMINATED · started May 20, 2019ClinicalTrials.gov NCT03861403 · fetched Nov 12, 2026
- A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1PHASE1_PHASE2 · TERMINATED · started Apr 1, 2019ClinicalTrials.gov NCT03837353 · fetched Nov 12, 2026
- A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or CarcinosarcomaPHASE2 · COMPLETED · started Mar 5, 2018ClinicalTrials.gov NCT03395080 · fetched Nov 12, 2026
- Phase 1 Open-label Study of TRX518 Monotherapy and TRX518 in Combination With Gemcitabine, Pembrolizumab, or NivolumabPHASE1 · COMPLETED · started Jan 1, 2016ClinicalTrials.gov NCT02628574 · fetched Nov 12, 2026
- Study of DKN-01 and Gemcitabine/Cisplatin in Patients With Carcinoma to Primary to the Intra- or Extra-Hepatic Biliary System or GallbladderPHASE1 · COMPLETED · started Jun 1, 2015ClinicalTrials.gov NCT02375880 · fetched Nov 12, 2026
- A Study of DKN-01 in Combination With Paclitaxel or PembrolizumabPHASE1 · COMPLETED · started May 5, 2014ClinicalTrials.gov NCT02013154 · fetched Nov 12, 2026
- A Study of DKN-01 and Lenalidomide/Dexamethasone in Patients With Relapsed or Refractory Multiple MyelomaPHASE1 · COMPLETED · started May 1, 2013ClinicalTrials.gov NCT01711671 · fetched Nov 12, 2026
- Trial of TRX518 (Anti-GITR mAb) in Stage III or IV Malignant Melanoma or Other Solid TumorsPHASE1 · COMPLETED · started Oct 1, 2010ClinicalTrials.gov NCT01239134 · fetched Nov 12, 2026
- Expanded Access Use of DKN-01 for the Treatment of Advanced Solid TumorsNO_LONGER_AVAILABLEClinicalTrials.gov NCT04681248 · fetched Nov 12, 2026