Biotech · Private company
Sierra Oncology LLC - a GSK company
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Clinical trials170 recruiting or active
Pipeline programs22From trials and the company's site
Disclosed deals0None found yet
Cash runwayNot availablePrivate: no SEC financials
Pipeline22
- Best Available Therapy (BAT)Phase 3 · Primary Myelofibrosis (PMF)ClinicalTrials.gov · fetched Nov 12, 2026
- DanazolPhase 3 · Primary MyelofibrosisClinicalTrials.gov · fetched Nov 12, 2026
- GemcitabinePhase 3 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- MomelotinibPhase 3 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- MomelotinibPhase 3 · Primary Myelofibrosis (PMF)ClinicalTrials.gov · fetched Nov 12, 2026
- MomelotinibPhase 3 · Primary MyelofibrosisClinicalTrials.gov · fetched Nov 12, 2026
- Nab-paclitaxelPhase 3 · Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- RuxolitinibPhase 3 · Primary MyelofibrosisClinicalTrials.gov · fetched Nov 12, 2026
- CYT387Phase 2 · Primary MyelofibrosisClinicalTrials.gov · fetched Nov 12, 2026
- MMBPhase 2 · Primary Myelofibrosis (PMF)ClinicalTrials.gov · fetched Nov 12, 2026
- MomelotinibPhase 2 · Polycythemia VeraClinicalTrials.gov · fetched Nov 12, 2026
- PNT2258Phase 2 · Lymphoma, Diffuse Large B-CellClinicalTrials.gov · fetched Nov 12, 2026
- PNT2258Phase 2 · Richter's TransformationClinicalTrials.gov · fetched Nov 12, 2026
- PNT2258Phase 2 · Lymphoma, Non-Hodgkin'sClinicalTrials.gov · fetched Nov 12, 2026
- CapecitabinePhase 1 · Relapsed/Refractory Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- ErlotinibPhase 1 · EGFR Mutated EGFR TKI Naive Metastatic NSCLCClinicalTrials.gov · fetched Nov 12, 2026
- Momelotinib (MMB)Phase 1 · Relapsed/Refractory Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- Momelotinib (MMB)Phase 1 · EGFR Mutated EGFR TKI Naive Metastatic NSCLCClinicalTrials.gov · fetched Nov 12, 2026
- Momelotinib (MMB)Phase 1 · Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
- OxaliplatinPhase 1 · Relapsed/Refractory Metastatic Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
- PNT2258Phase 1 · CancerClinicalTrials.gov · fetched Nov 12, 2026
- TrametinibPhase 1 · Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
Clinical trials17
- A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)PHASE3 · COMPLETED · started Feb 7, 2020ClinicalTrials.gov NCT04173494 · fetched Nov 12, 2026
- Momelotinib in Transfusion-Dependent Adults With Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF)PHASE2 · COMPLETED · started Jan 29, 2016ClinicalTrials.gov NCT02515630 · fetched Nov 12, 2026
- PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)PHASE2 · TERMINATED · started Aug 1, 2015ClinicalTrials.gov NCT02378038 · fetched Nov 12, 2026
- Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in PhasePHASE1 · TERMINATED · started Mar 11, 2015ClinicalTrials.gov NCT02258607 · fetched Nov 12, 2026
- PNT2258 for Treatment of Patients With r/r DLBCL (Wolverine)PHASE2 · COMPLETED · started Dec 1, 2014ClinicalTrials.gov NCT02226965 · fetched Nov 12, 2026
- Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal AdenocarcinomaPHASE1 · TERMINATED · started Nov 5, 2014ClinicalTrials.gov NCT02244489 · fetched Nov 12, 2026
- Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)PHASE1 · TERMINATED · started Oct 16, 2014ClinicalTrials.gov NCT02206763 · fetched Nov 12, 2026
- Efficacy of Momelotinib Versus Best Available Therapy in Anemic or Thrombocytopenic Subjects With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MFPHASE3 · COMPLETED · started Jun 19, 2014ClinicalTrials.gov NCT02101268 · fetched Nov 12, 2026
- Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal AdenocarcinomaPHASE3 · TERMINATED · started Jun 2, 2014ClinicalTrials.gov NCT02101021 · fetched Nov 12, 2026
- Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential ThrombocythemiaPHASE2 · COMPLETED · started Apr 30, 2014ClinicalTrials.gov NCT02124746 · fetched Nov 12, 2026
- Safety and Efficacy of Momelotinib in Subjects With Polycythemia Vera or Essential ThrombocythemiaPHASE2 · TERMINATED · started Feb 19, 2014ClinicalTrials.gov NCT01998828 · fetched Nov 12, 2026
- Momelotinib Versus Ruxolitinib in Subjects With MyelofibrosisPHASE3 · COMPLETED · started Dec 6, 2013ClinicalTrials.gov NCT01969838 · fetched Nov 12, 2026
- Study of PNT2258 for Treatment of Relapsed or Refractory Non-Hodgkin's LymphomaPHASE2 · COMPLETED · started Nov 1, 2012ClinicalTrials.gov NCT01733238 · fetched Nov 12, 2026
- Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia MyelofibrosisPHASE1_PHASE2 · COMPLETED · started Aug 1, 2011ClinicalTrials.gov NCT01423058 · fetched Nov 12, 2026
- Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)PHASE2 · COMPLETED · started Nov 1, 2010ClinicalTrials.gov NCT01236638 · fetched Nov 12, 2026
- A Study of PNT2258 in Patients With Advanced Solid TumorsPHASE1 · COMPLETED · started Aug 1, 2010ClinicalTrials.gov NCT01191775 · fetched Nov 12, 2026
- Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)PHASE1_PHASE2 · COMPLETED · started Nov 1, 2009ClinicalTrials.gov NCT00935987 · fetched Nov 12, 2026