Biotech · Public company · Cambridge, MA, US

Spero Therapeutics, Inc.

Ticker SPRO · SEC CIK 0001701108

Track this companyFree. Adds Spero Therapeutics, Inc. to your Dealase workspace and tells you when its record changes.

Clinical trials160 recruiting or active

Pipeline programs26From trials and the company's site

Disclosed deals0None found yet

Cash runwayNot availableNo recent cash burn filed

Pipeline26

Dummy InfusionPhase 3 · Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
Dummy InfusionPhase 3 · Complicated Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
Dummy tabletsPhase 3 · Complicated Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
Dummy TabletsPhase 3 · Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
ErtapenemPhase 3 · Complicated Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
Imipenem-cilastatinPhase 3 · Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
TBP-PI-HBrPhase 3 · Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
TBPM-PI-HBrPhase 3 · Complicated Urinary Tract InfectionClinicalTrials.gov · fetched Nov 12, 2026
SPR720Phase 2 · Mycobacterium Avium ComplexClinicalTrials.gov · fetched Nov 12, 2026
SPR720 1000 mgPhase 2 · Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)ClinicalTrials.gov · fetched Nov 12, 2026
SPR720 500 mgPhase 2 · Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)ClinicalTrials.gov · fetched Nov 12, 2026
20 mL aluminum hydroxide/magnesium hydroxide/simethicone (400 mg aluminum hydroxide/400 mg magnesium hydroxide/40 mg simethicone per 5 mL)Phase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
AzithromycinPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
EthambutolPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Moxifloxacin 400mgPhase 1 · TQT StudyClinicalTrials.gov · fetched Nov 12, 2026
OmeprazolePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
SPR720Phase 1 · Healthy VolunteerClinicalTrials.gov · fetched Nov 12, 2026
SPR720Phase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
TBP-PI-HBrPhase 1 · Healthy ParticipantsClinicalTrials.gov · fetched Nov 12, 2026
TBP-PI-HBrPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
TBPM-PI-HBrPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)Phase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Tebipenem pivoxil hydrobromide (TBPM-PI-HBr)Phase 1 · Renal ImpairmentClinicalTrials.gov · fetched Nov 12, 2026
Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr)Phase 1 · TQT StudyClinicalTrials.gov · fetched Nov 12, 2026
Tebipenem pivoxil hydrobromide (TBPM-PI-HBr) - ReferencePhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026
Tebipenem pivoxil hydrobromide (TBPM-PI-HBr) - TestPhase 1 · Healthy VolunteersClinicalTrials.gov · fetched Nov 12, 2026

Clinical trials16

A Study to Characterize Single and Repeat Dose Pharmacokinetics of Tebipenem-Pivoxil-Hydrobromide (TBP-PI-HBr) and Its Major Metabolite (SPR1349) in Healthy ParticipantsPHASE1 · COMPLETED · started Nov 20, 2024ClinicalTrials.gov NCT06727136 · fetched Nov 12, 2026
A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)PHASE3 · COMPLETED · started Dec 21, 2023ClinicalTrials.gov NCT06059846 · fetched Nov 12, 2026
A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy ParticipantsPHASE1 · COMPLETED · started Aug 4, 2023ClinicalTrials.gov NCT05966688 · fetched Nov 12, 2026
A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.PHASE1 · COMPLETED · started Aug 1, 2023ClinicalTrials.gov NCT05955586 · fetched Nov 12, 2026
A Study to Compare Two Bioanalytical Assays for TebipenemPHASE1 · COMPLETED · started May 4, 2023ClinicalTrials.gov NCT05856747 · fetched Nov 12, 2026
A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of SPR720 as Compared With Placebo for the Treatment of Participants With Mycobacterium Avium Complex (MAC) Pulmonary DiseasePHASE2 · COMPLETED · started Dec 14, 2022ClinicalTrials.gov NCT05496374 · fetched Nov 12, 2026
Bioavailability of Tebipenem (SPR994) Crushed TabletPHASE1 · COMPLETED · started Apr 1, 2022ClinicalTrials.gov NCT05296382 · fetched Nov 12, 2026
Tebipenem (SPR994) Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo MicrodialysisPHASE1 · COMPLETED · started Jul 1, 2021ClinicalTrials.gov NCT04919954 · fetched Nov 12, 2026
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking VolunteersPHASE1 · COMPLETED · started Dec 7, 2020ClinicalTrials.gov NCT04710407 · fetched Nov 12, 2026
Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary DiseasePHASE2 · TERMINATED · started Dec 3, 2020ClinicalTrials.gov NCT04553406 · fetched Nov 12, 2026
Study of the Absorption, Metabolism, and Excretion of [14C]-Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) Following a Single Oral Dose in Healthy Male SubjectsPHASE1 · COMPLETED · started Sep 30, 2020ClinicalTrials.gov NCT04625855 · fetched Nov 12, 2026
Study to Examine the Effect of Antacid and Omeprazole on the Single-Dose Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult SubjectsPHASE1 · COMPLETED · started Jul 1, 2020ClinicalTrials.gov NCT04368585 · fetched Nov 12, 2026
Bioequivalence Study Comparing Two Tablet Formulations of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Healthy Adult SubjectsPHASE1 · COMPLETED · started Jun 1, 2020ClinicalTrials.gov NCT04421885 · fetched Nov 12, 2026
A Single-Dose, Randomized, Placebo- and Active-Control, Four-Way, Cross-Over Study for the Evaluation of the Effect of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) on the QT/QTc Intervals in Adult Healthy SubjectsPHASE1 · COMPLETED · started Jan 19, 2020ClinicalTrials.gov NCT04238195 · fetched Nov 12, 2026
Phase 1 Study of PK and Safety of Tebipenem Pivoxil Hydrobromide (TBPM-PI-HBr) in Subjects With Various Degrees Of Renal FunctionPHASE1 · COMPLETED · started Dec 6, 2019ClinicalTrials.gov NCT04178577 · fetched Nov 12, 2026
Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)PHASE3 · COMPLETED · started Jun 3, 2019ClinicalTrials.gov NCT03788967 · fetched Nov 12, 2026

SEC filings12

8-K · 8-KSEC EDGAR · filed Nov 10, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Oct 27, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Aug 28, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Aug 12, 2026 · fetched Nov 12, 2026
10-Q · 10-QSEC EDGAR · filed Aug 12, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Jul 14, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Jun 25, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Jun 22, 2026 · fetched Nov 12, 2026
10-Q · 10-QSEC EDGAR · filed May 13, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed May 13, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed Mar 26, 2026 · fetched Nov 12, 2026
10-K · 10-KSEC EDGAR · filed Mar 26, 2026 · fetched Nov 12, 2026

NIH awards1

Development of Therapeutic Products for Biodefense, AntiMicrobial Resistant (AMR) Infections and Emerging Infectious DiseasesFiscal year 2024 · $3.4MNIH RePORTER 75N93021C00022-P00012-9999-1 · fetched Nov 12, 2026