Biotech · Public company · Needham, MA, US

Verastem, Inc.

Ticker VSTM · SEC CIK 0001526119

Track this companyFree. Adds Verastem, Inc. to your Dealase workspace and tells you when its record changes.

Clinical trials2520 recruiting or active

Pipeline programs25From trials and the company's site

Disclosed deals0None found yet

Cash runwayNot availableNo recent cash burn filed

Pipeline25

AnastrozolePhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
avutometinibPhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
DefactinibPhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
LetrozolePhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
PaclitaxelPhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
Pegylated liposomal doxorubicinPhase 3 · Low Grade Serous Ovarian CancerClinicalTrials.gov · fetched Nov 12, 2026
avutometinib (VS-6766)Phase 2 · Low Grade Ovarian Serous AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
avutometinib (VS-6766) and adagrasibPhase 2 · Non Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
avutometinib (VS-6766) and defactinibPhase 2 · Low Grade Ovarian Serous AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxelPhase 2 · KRAS Activating MutationClinicalTrials.gov · fetched Nov 12, 2026
avutometinib and sotorasibPhase 2 · Non Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
avutometinib and sotorasib and defactinibPhase 2 · Non Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
Carboplatin + Pemetrexed + PembrolizumabPhase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
cetuximabPhase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
CetuximabPhase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
cetuximab (or panitumumab if α-gal IgE+ or cetuximab reaction)Phase 2 · Pancreatic Ductal Adenocarcinoma (PDAC)ClinicalTrials.gov · fetched Nov 12, 2026
Cetuximab + mFOLFOX6Phase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
DefactinibPhase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
Gemcitabine + Nab-paclitaxelPhase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
panitumumabPhase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
PembrolizumabPhase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
VS-7375Phase 2 · Colorectal CancerClinicalTrials.gov · fetched Nov 12, 2026
VS-7375Phase 2 · Non-Small Cell Lung CancerClinicalTrials.gov · fetched Nov 12, 2026
VS-7375Phase 2 · Pancreatic Ductal AdenocarcinomaClinicalTrials.gov · fetched Nov 12, 2026
VS-7375Phase 2 · Pancreatic Ductal Adenocarcinoma (PDAC)ClinicalTrials.gov · fetched Nov 12, 2026

Clinical trials25

Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic AdenocarcinomaPHASE1_PHASE2 · NOT_YET_RECRUITING · started Oct 1, 2026ClinicalTrials.gov NCT07824960 · fetched Nov 12, 2026
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal CancerPHASE2 · RECRUITING · started Jul 28, 2026ClinicalTrials.gov NCT07659795 · fetched Nov 12, 2026
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung CancerPHASE2 · RECRUITING · started Jul 22, 2026ClinicalTrials.gov NCT07659782 · fetched Nov 12, 2026
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic CancerPHASE2 · RECRUITING · started Jun 16, 2026ClinicalTrials.gov NCT07644559 · fetched Nov 12, 2026
Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial CancerPHASE1 · RECRUITING · started May 13, 2026ClinicalTrials.gov NCT07318324 · fetched Nov 12, 2026
Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic AdenocarcinomaPHASE2 · RECRUITING · started Apr 10, 2026ClinicalTrials.gov NCT07126158 · fetched Nov 12, 2026
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid TumorsPHASE1_PHASE2 · RECRUITING · started Jun 24, 2025ClinicalTrials.gov NCT07020221 · fetched Nov 12, 2026
Avutometinib and Defactinib in Diffuse Gastric CancerPHASE2 · RECRUITING · started Oct 28, 2024ClinicalTrials.gov NCT06487221 · fetched Nov 12, 2026
A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian CancerPHASE2 · RECRUITING · started Apr 29, 2024ClinicalTrials.gov NCT06394804 · fetched Nov 12, 2026
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous MelanomaPHASE1_PHASE2 · RECRUITING · started Mar 20, 2024ClinicalTrials.gov NCT06194929 · fetched Nov 12, 2026
A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian CancerPHASE3 · RECRUITING · started Mar 18, 2024ClinicalTrials.gov NCT06072781 · fetched Nov 12, 2026
A Study of Avutometinib and Defactinib in People With Thyroid CancerPHASE2 · RECRUITING · started Aug 16, 2023ClinicalTrials.gov NCT06007924 · fetched Nov 12, 2026
Identification of Treatment Concentrations of Defactinib or VS-6766 for the Treatment of Patients With GlioblastomaEARLY_PHASE1 · ACTIVE_NOT_RECRUITING · started Jul 28, 2023ClinicalTrials.gov NCT05798507 · fetched Nov 12, 2026
Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic CancerPHASE1_PHASE2 · ACTIVE_NOT_RECRUITING · started Mar 22, 2023ClinicalTrials.gov NCT05669482 · fetched Nov 12, 2026
A Study of Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic CancerPHASE2 · ACTIVE_NOT_RECRUITING · started Mar 15, 2023ClinicalTrials.gov NCT05787561 · fetched Nov 12, 2026
VS-6766+Abema+Fulv in Met HR+/HER- BCPHASE1_PHASE2 · RECRUITING · started Feb 23, 2023ClinicalTrials.gov NCT05608252 · fetched Nov 12, 2026
A Phase 2 Study of Avutometinib (VS-6766) Plus DefactinibPHASE2 · RECRUITING · started Feb 6, 2023ClinicalTrials.gov NCT05512208 · fetched Nov 12, 2026
A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal CancerPHASE1_PHASE2 · SUSPENDED · started Aug 22, 2022ClinicalTrials.gov NCT05200442 · fetched Nov 12, 2026
Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC PatientsPHASE1_PHASE2 · COMPLETED · started Aug 1, 2022ClinicalTrials.gov NCT05375994 · fetched Nov 12, 2026
Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC PatientsPHASE1_PHASE2 · ACTIVE_NOT_RECRUITING · started Apr 12, 2022ClinicalTrials.gov NCT05074810 · fetched Nov 12, 2026
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas AdenocarcinomaPHASE2 · ACTIVE_NOT_RECRUITING · started Aug 24, 2021ClinicalTrials.gov NCT04331041 · fetched Nov 12, 2026
Defactinib and VS-6766 for the Treatment of Patients With Metastatic Uveal MelanomaPHASE2 · TERMINATED · started Jan 26, 2021ClinicalTrials.gov NCT04720417 · fetched Nov 12, 2026
A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS MutationPHASE2 · ACTIVE_NOT_RECRUITING · started Dec 21, 2020ClinicalTrials.gov NCT04625270 · fetched Nov 12, 2026
Study of Pembrolizumab With or Without Defactinib Following Chemotherapy as a Neoadjuvant and Adjuvant Treatment for Resectable Pancreatic Ductal AdenocarcinomaPHASE2 · COMPLETED · started Jun 4, 2019ClinicalTrials.gov NCT03727880 · fetched Nov 12, 2026
ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAKPHASE1_PHASE2 · TERMINATED · started Feb 6, 2018ClinicalTrials.gov NCT03287271 · fetched Nov 12, 2026

SEC filings12

8-K · FORM 8-KSEC EDGAR · filed Nov 5, 2026 · fetched Nov 12, 2026
10-Q · 10-QSEC EDGAR · filed Nov 5, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Oct 14, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Oct 14, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Aug 7, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Aug 6, 2026 · fetched Nov 12, 2026
10-Q · 10-QSEC EDGAR · filed Aug 6, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Jun 23, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed Jun 17, 2026 · fetched Nov 12, 2026
8-K · 8-KSEC EDGAR · filed May 26, 2026 · fetched Nov 12, 2026
8-K · FORM 8-KSEC EDGAR · filed May 7, 2026 · fetched Nov 12, 2026
10-Q · 10-QSEC EDGAR · filed May 7, 2026 · fetched Nov 12, 2026